Siloxane nanoparticles unlock precise organ targeting for mRNA therapy Changes to chemical structure allow for tissue-specific delivery Date: October 1, 2024 ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Details appeared recently in Nature Biomedical Engineering, in an article titled, “Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical ...

We’re also looking at ways to temporarily change the mRNA chemical structure to keep it from degrading in the vial, then have it revert to its native form in the body.” In substances that rely on mRNA ...

The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

In a new paper published in Nature Nanotechnology ("Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery"), ...

Scientists have discovered the internal shape of tiny drug-delivery particles - called lipid nanoparticles - has a big impact ...

They tested mRNA structures with zero to three branches and three different kinds of chemical modifications. The modifications were phosphorothioate (PS), DNA, and 2’-O-methoxyethyl (2MOE).

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

Mammalian Oocytes Store mRNA in Newly Found Membraneless Structure. The findings answer the longstanding question of where these cells hold the mRNA needed to cope with the transcriptional halt ...