In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

As dysfunctional lysosomal activity is linked to inflammation, Harvey et al. focus on nuclear receptor coactivator 7 (NCOA7), which binds to V-ATPases to modulate lysosomal function and is up ...

Interest in lysosomal storage diseases (LSDs) has increased significantly, because several new therapeutics received FDA approval in 2003. Though long overlooked by most major pharmaceutical ...

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by ...