Gut microbiota produce trimethylamine, which enters the liver via the portal circulation and is primarily oxidized by FMO3 to produce TMAO. TMAO upregulates hepatic PCSK9 gene expression while ...

Lithogenesis der Gegenwart. Beobachtungen über die Bildung der Gesteine an der heutigen Erdoberfläche. Dritter Theil einer Einleitung in die Geologie als historische Wissenschaft. By Johannes ...

However, the underlying mechanisms of TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore the specific molecular mechanisms through which TMAO promotes gallstone ...