The keratoderma-like phenotype we observe is associated with reduced expression of differentiation-associated cutaneous keratins, and increased expression of hyperproliferation-associated (Krt6a ...

Financing co-led by new investor BRM Group and existing investor Pontifax. Lead program KM023 is a first-in-class oral TRPV3 inhibitor entering clinical development for the treatm ...

Figure 1 shows the psoriasiform, hyperkeratotic plaques typical of keratoderma blennorrhagicum (i.e., the acral pustular and hyperkeratotic lesions seen in Reiter's syndrome and pustular psoriasis 1).

This page lists all known medications that could potentially lead to 'Acquired keratoderma' as a side effect. It's important to note that mild side effects are quite common with medications.

Pachyonychia congenita (PC) is a rare form of hereditary palmoplantar keratoderma (PPK) (Smith et al., 2001) and is a genetic disorder of keratinization that affects the nails, skin (particularly ...

Both viral warts and keratoderma are benign but can cause problems on the hands. Failing to differentiate them can lead to inappropriate treatment - as occurred with the patient pictured here with ...

TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel that functions as a regulator of skin homeostasis. The epidermal overexpression of TRPV3 is linked to dermatological ...

83% of families had a genetic diagnosis of palmoplantar keratoderma (PPK). The most common genotype found in patients was AAGAB which was linked to punctate PPK. Researchers found genetic ...

Genetic counseling and molecular genetic studies are recommended to detect mutations in the affected keratin genes. Family screening for genetic disease and advice about consanguinity marriage and ...

Foot callouses/keratoderma (thickened skin) can be linked to cancer of the esophagus (gullet), report researchers. Scientists from Queen Mary University of London have discovered that foot ...

About Palmoplantar KeratodermaPalmoplantar keratoderma (PPK) is a group of skin conditions characterized by the thickening of the skin on the palms and soles of the feet. PPK may lead to ...