Isogenic refers to a population with essentially identical genes. There are techniques available that can modify the DNA of cells, and this can then be used as a disease model. For example ...

Figure 7: Effect of SC-D on tumor xenografts. The results described above show that isogenic human cancer cell lines can be used in high-throughput screens to discover new lead compounds.

A team of researchers from Michigan State University, Indiana University, The Ohio State University and Tulane University, has conducted a top-down proteomics study of isogenic human non ...

CRISPR-edited isogenic cell models offer a more relevant option for studying disease progression and therapeutic efficacy. By targeting specific genes and generating disease-causing mutations, it's ...

The iCell Blood-Brain Barrier Isogenic Kit is an off-the-shelf, ready to use, human iPSC-derived cell model that has barrier integrity and functionality consistent with in vivo physiological ...

Episode 10 (February 23, 2024): Researchers from Francis Collins’ lab developed an efficient CRISPR prime editing protocol to generate isogenic-induced pluripotent stem cell (iPSC) lines ...

Less than 10% of preclinical animal studies are translated to humans, meaning there is a need for better human models of disease for research and drug discovery. Patient-derived induced pluripotent ...

Bacterial populations pose an intriguing puzzle: in so-called isogenic populations, all bacteria have the same genes, but they still behave differently, for example grow at different speeds.

Cancer researchers are challenged by the lack of precise disease models. Genome editing was used to create an isogenic lung cancer cell line that was tested for drug sensitivity.

Metastatic pattern of late metastases of gastrointestinal stromal tumors and the contribution radiation therapy for disease control. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting ...