在眼科疾病领域，Fuchs 内皮角膜营养不良（FECD）是一种令人头疼的双侧、渐进性角膜内皮疾病。它的典型特征是角膜中央会出现一种名为 “滴状赘生物（guttae）” 的细胞外基质（ECM）赘生物。随着病情发展，guttae 数量不断增加，尤其是在角膜中央区域 ...

Clinically visible deposits called guttae develop under the corneal endothelium in patients with FCD. A loss of endothelial cells and deposition of an abnormal extracellular matrix are observed ...

FECD is the most common reason for corneal transplantation in the Unites States. “The first signs of FECD are microscopic mounds of material, called ‘guttae,’ generated by the diseased corneal ...

The study included 3,281 eyes of 1,971 patients classified according to disease severity: stage 0, no guttae; stage 1, guttata cornea without edema; stage 2, mild Fuchs' dystrophy; and stage 3 ...