Complement 3 (C3) glomerulopathy is a rare disease that affects your kidneys – the organs that filter waste from your blood. It's a progressive condition, which means that it gradually causes ...

Current treatment methods for C3 glomerulopathy (C3G) help support kidney function and suppress immune system activity. Emerging therapies interrupt the proteins responsible for disease activity.

C3G and IC-MPGN both cause protein deposits that reduce kidney function. Overactive proteins in the immune system lead to these different conditions. C3G and IC-MPGN are rare kidney conditions ...

Findings from the APPEAR-C3G trial showed a 35% reduction in 24-hour UPCR from baseline (primary endpoint) in the iptacopan group compared with the placebo group. The Food and Drug Administration ...

STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are ...

How does C3 glomerulopathy affect the body, and why is this progressive kidney disease so rare? We don't know exactly why it is so rare because we frankly don't know why some people actually ...

The FDA has approved Novartis’ Fabhalta (iptacopan) as the first and only treatment for C3 glomerulopathy (C3G). Previously, patients with C3G were forced to rely on supportive care and broad ...

The FDA approved iptacopan (Fabhalta) as the first treatment to reduce proteinuria in adults with complement 3 glomerulopathy (C3G), the agency announced Thursday. "C3G is a debilitating disease ...

FABHALTA is a prescription medicine used to treat adults with a kidney disease called complement 3 glomerulopathy (C3G), to reduce protein in the urine (proteinuria). It is not known if FABHALTA ...

Iptacopan's (Fabhalta; Novartis) approval makes it the first and only treatment approved for C3 glomerulopathy. The FDA approved oral iptacopan (Fabhalta; Novartis) to reduce proteinuria in adults ...

A new study published in the journal of BMC Nephrology showed that C3 Granulopathy + pregnancy is linked to a higher risk of ...

This is usually caused either by an auto-immune disease or diabetes and it is quite rare. It can not be cured but it can be managed. Deposits of micro fibrils ( like hairs) damage the glomerula or the ...