Development of a DNA Methylation–Based Diagnostic Signature to Distinguish Benign Oncocytoma From Renal Cell Carcinoma As paired germline and tumor analysis becomes more common in oncology clinics, ...

An online platform may help increase access to and reduce barriers associated with germline testing for individuals with cancer, according to findings presented at ASCO Annual Meeting.An analysis of ...

Patients with stages I to III breast cancer who were seen at a single cancer center between 2010 and 2012, and who agreed to participate in research DNA banking, were included (N = 488). Personal and ...

Genetic testing for hereditary cancer unexpectedly uncovered a case of myelodysplastic syndrome (MDS), highlighting the need ...

Dr. Kristen Scarpato explains the role of genetic testing in prostate cancer care, as well as its use in determining ...

We analyzed the DNA sequences of 565 genes, including 60 that have been associated with autosomal dominant cancer-predisposition syndromes, for the presence of germline mutations. The ...

Instead, they point to the active involvement of gene sequences inherited from our parents—our germline genome—in determining whether cells bearing potential cancer-causing mutations are ...

During the 19th century, even before DNA was recognized as the material of heredity, the German evolutionary biologist August Weismann theorized that organisms might protect their genetic heritage by ...

Researchers and ethicists, including the scientist who pioneered and patented CRISPR gene-editing technology, are calling for a global moratorium on human germline editing – changes made to ...

The move left many researchers wondering whether the specter of accidental germline transmission — which haunted early gene therapy trials — had now risen over the field of gene editing.