难治性全身型重症肌无力（generalized MG，gMG）是一类对常规免疫治疗药物（激素和非激素类免疫抑制剂）反应有限、不能耐受药物的不良反应或病情易反复、难以达到症状缓解或微小状态的治疗目标的疾病[1]。其住院率、病死率、机械通气使用率更高，医疗花费更多。

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