The heterogeneity of fibroblasts is key to developing targeted therapies in regenerative medicine and in the treatment of ...

Fibroblasts are the main connective tissue cells present in the body. As well as being present as fibroblasts, these cells exist in an alternative state, as fibrocytes. Fibroblast is the term used ...

Synovial fibroblasts, even when isolated from the rheumatoid joint, proliferate and resist cell death in culture. When injected into mice, these fibroblasts migrate to distant joints. 1 Synovial ...

The main function of fibroblasts is to produce the extracellular matrix and collagen needed for animal tissues. Together, these form the structural framework of tissues in animals and play an ...

To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

Resting or quiescent adult fibroblasts are indolent and probably remnants of mesenchymal cells during organ development. Resting fibroblasts serve as precursors of activated fibroblasts including ...

4 For their current study, Garza and his team built on this and more recent work reporting that fibroblasts have positional memory. 5 “We realized we could take the fibroblasts out of a person and ...

Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

A surprising level of activity discovered in "sleepy" cells throughout the human body could be a key to good health. Fibroblasts, which are found in connective tissue such as ligaments and tendons, ...

"We discovered that an increased frequency of erections leads to more fibroblasts that enable erection and vice versa, that a decreased frequency results in fewer of these cells," says principal ...

Cancer-associated fibroblasts (CAFs) get a bad rap. The protective, gel-like complex surrounding tumors have been thought to be a no-go for drugs and are known to enforce treatment resistance.

Challenging the long-standing belief that fibroblasts produce skin collagen, researchers have investigated collagen formation in the 'glass-skinned' amphibian axolotl and other vertebrates.