Fibroblasts are a key cellular component of tumours. Activated fibroblasts (which are sometimes referred to as myofibroblasts) that are found in association with cancer cells are known as ...

Resting or quiescent adult fibroblasts are indolent and probably remnants of mesenchymal cells during organ development. Resting fibroblasts serve as precursors of activated fibroblasts including ...

The heterogeneity of fibroblasts is key to developing targeted therapies in regenerative medicine and in the treatment of ...

Fibroblasts play a central role in maintaining healthy tissue structures, as well as in the development and progression of ...

Synovial fibroblasts, even when isolated from the rheumatoid joint, proliferate and resist cell death in culture. When injected into mice, these fibroblasts migrate to distant joints. 1 Synovial ...

To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

Fibroblasts are the main connective tissue cells present in the body. As well as being present as fibroblasts, these cells exist in an alternative state, as fibrocytes. Fibroblast is the term used ...

The main function of fibroblasts is to produce the extracellular matrix and collagen needed for animal tissues. Together, these form the structural framework of tissues in animals and play an ...

4 For their current study, Garza and his team built on this and more recent work reporting that fibroblasts have positional memory. 5 “We realized we could take the fibroblasts out of a person and ...

Cancer-associated fibroblasts (CAFs) get a bad rap. The protective, gel-like complex surrounding tumors have been thought to be a no-go for drugs and are known to enforce treatment resistance.