Sequence analysis reveals that the C-terminus of hPMC2 encodes a putative exonuclease domain. Using in vitro kinetic assays, we found that hPMC2 is a 3′–5′ non-processive exonuclease that ...

Methods: We are recruiting patients with curatively resected, stage III colon cancer which are dMMR or have a centrally confirmed POLE exonuclease domain mutation. Eligible patients are randomised in ...

Triple-negative breast cancer remodeling of the tissue immune microenvironment by regulation of embryonic-derived tissue-resident macrophage polarization through the IRF7/CH25H/25HC pathway.

The Family DNA polymerases include Tth and Tma DNA polymerase alongside Taq and have 5′-3′ exonuclease activity, but normally lack 3′-5′. In the absence of the 3′-5′ exonuclease ...