Histologically, ependymomas are graded in a two-tiered scheme (Grade II or III) in the current WHO classification, while variants such as myxopapillary ependymoma or sub-ependymoma are considered ...

Jude Children's Research Hospital. Brain tumors called ependymomas that occur in different parts of thecentral nervous system appear to arise from subpopulations of stemcells called radial glia ...

In children, 90% of ependymomas arise intracranially, with two-thirds occurring as posterior fossa group A (PFA) tumors, the most common and aggressive of three distinct disease subtypes, which has ...

[4] The present study has attempted to evaluate CD99 as a possible specific marker that could selectively differentiate ependymomas from other CNS tumors. Both CD99 and EMA were also evaluated ...

Mutant-specific immunohistochemistry for H3 K27M showed strong staining of the tumor cell nuclei (C). Ependymomas represent the third most common pediatric brain tumor, accounting for 30% of ...

Ependymomas usually start from ependymal cells. These cells line the fluid filled areas of the brain (ventricles) and the spinal cord. Ependymomas are most common in children under 5 years old. They ...

The researchers further demonstrate that ependymomas develop in a specific stem cell niche of the brain. These findings could explain why some ependymomas behave very aggressively and are ...

The researchers further demonstrate that ependymomas develop in a specific stem cell niche of the brain. These findings could explain why some ependymomas behave very aggressively and are ...

The 38 cases of the ependymal tumors included 29 classic ependymomas, 3 tanycytic, 3 myxopapillary, and 3 anaplastic ependymomas. The 41 nonependymal tumors consist of 6 astrocytomas, 4 central ...

A phase II trial of conventional radiation therapy (XRT) plus high dose tamoxifen (TAM) for the treatment of supratentorial glioblastoma multiforme (GBM): RTOG protocol BR-0021 ...