Their results showed that in adolescents, but not adults, cocaine reduces the activity of eIF2α. This leads to an increase in the strength of the connections, or synapses, between dopamine ...

Protein phosphatase 1C (PP1c) dephosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α), among a plethora of other protein targets. As part of the unfolded protein response (UPR ...