本研究针对全球性抑制双亮氨酸拉链激酶(DLK)引发神经轴突细胞骨架破坏的临床困境，通过高通量筛选发现选择性抑制DLK急性轴突棕榈酰化的化合物8和13。该研究揭示TD（营养因子剥夺）诱导的DLK棕榈酰化是其招募至轴突囊泡并启动逆行信号的关键步骤，化合物8/ ...

双亮氨酸拉链激酶（DLK）（又名MAP3K12）是混合系谱激酶（MLK）家族的成员，它包含一个N-末端激酶结构域，后面跟着两个亮氨酸拉链结构域以及一个 ...

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An enzyme known as dual leucine-zipper kinase (DLK) plays a key role in this process, telling neurons that are damaged or unhealthy when they should cut their losses and self-destruct. While ...