Nevertheless, loss of DNA methylation, or DNA demethylation, has been observed in different biological contexts and this alteration can take place actively or passively. Active DNA demethylation ...

近日，Genome Biology在线发表了华中农业大学玉米团队题为“DNA demethylation affects imprinted gene expression in maize endosperm”的研究论文。该研究揭示了DNA去 ...

北京大学生命科学学院钱伟强课题组联合贺新强课题组，在Science Advances在线发表题为“Active DNA demethylation regulates tracheary element differentiation in ...

By combining analysis of patient samples with CRISPR-DiR technology, we found that demethylation and up-regulation of an oncogene after treatment with a hypomethylating agent can indeed occur and ...

Reversing this modification requires DNA demethylation, a series of enzymatic reactions which starts with the creation of 5-hydroxymethylcytosine (5hmC). But 5hmC is not just a transient step in ...

TET enzymes control gene expression by triggering a process called demethylation, where a molecule called a methyl group is removed from where it sits in the genetic code. Demethylation is ...

Histone H3K27 methylation status is regulated by the addition of methyl (Me) groups by the enzyme EZH2 and demethylation by UTX and JMJD3 histone demethylases (Panel A). Lochmann et al.

Safety and efficacy of eniluracil + capecitabine (6422 + Cap) in phase 1b trial. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text ...

The experiments conducted by the group also demonstrated that the mechanistic connection between APC mutation and demethylation is conveyed through changes in the amount of retinoic acid (RA), an ...

To determine whether therapy with a DNA methyltransferase inhibitor is effective in achieving demethylation and gene re-expression in tumor DNA in patients. Biopsy specimens were obtained from ...