To circumvent this problem, we investigated gene delivery by a fiberless adenovirus vector retargeted with bifunctional antibodies. Although one previous study reported that fiberless virus ...

These studies demonstrate that targeted HVR modification strategies can be used to construct chimaeric rAd5 vectors that effectively circumvent anti-Ad5 immunity in both mice and rhesus monkeys.

The longstanding ambition of developing an inhaled gene therapy for cystic fibrosis has taken a step forward, with the start of a phase I/II trial of a product using a novel pseudotyped viral vector ...