Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease.

Acetylcholine in the prefrontal cortex modulates the impact of surprising outcomes on learning and decision-making.

Although compounds with a combined cholinergic–glutamatergic action have been trialed, none has yet been successful in the later stages of development (Table 4). Consequently, combination ...

Research shows that the drug activates the cannabinoid neurotransmitter system (which protects the brain), and this stimulates the cholinergic system (which controls memory and learning ...

Nicotine withdrawal induces behavioral symptoms such as tremors and shaking. Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine significantly ...