Catechol-O-methyltransferase (COMT): An enzyme that catalyzes the transfer of a methyl group to catecholamines, thereby inactivating them. Dopamine: A neurotransmitter that plays several important ...

When levodopa is administered with a DDCI, its main route of peripheral metabolism is via catechol-O-methyl transferase (COMT). A COMT inhibitor can be added to the combination of levodopa and a ...

In fluctuating Parkinson's disease (PD) patients, treatment of PD using the catechol-O-methyl transferase inhibitor entacapone with carbidopa/levodopa improves quality of life and activities of ...