Relebactam has been designed to inhibit a key resistance mechanism that limits the effectiveness of beta lactam antibiotics, including carbapenems like imipenem that have become last-line ...

Resistance to carbapenems in Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae, mainly determined by the production of carbapenem-hydrolyzing β-lactamases, has emerged ...

Summary. Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive ...

Carbapenems are last-resort antibiotics clinically significant drugs that are used when everything else fails. Unfortunately, like other antibiotics, their efficacy is being threatened by ...