These properties led Lee and colleagues to investigate cadherin molecule functioning in synovial lining and in autoimmune arthritis. Initial investigations in healthy mice demonstrated that ...

P-cadherin is embedded in the cell membrane as a dimer, or matched pair, with P-cadherin on the surface of an adjacent cell. This dimer can exist in two conformations: a more open, "strand-swap ...

One of the major constituents of the cell-adhesion complex in epithelial cells is E-cadherin, a transmembrane protein involved in homotypic cell–cell adhesion. E-cadherin exerts a potent ...

PRAGUE, Czech Republic and LONDON, UK I March 03, 2025 I SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, today presented the ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...