Here we show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is ...

Although the technique reliably produces iPSCs, cellular reprogramming with the four Yamanaka factors—Oct4, Sox2, Klf4, and cMyc (collectively ... while a synthetic factor that selectively adopts ...

Lu’s builds his work on the four transcription factors- Oct4, Sox2, Klf4, c-Myc discovered by Shinya Yamanaka. These factors can erase the cell’s epigenetic markers and return these cells to ...

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous ...