Here we show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is ...

本文聚焦细胞重编程用于改善与年龄相关细胞表型的研究。2006 年山中伸弥用 Oct4、Sox2、Klf4 和 c-Myc（OSKM）转录因子成功将小鼠体细胞重编程为诱导多能干细胞（iPSCs）。之后研究发现，在小鼠模型中诱导 OSKM 可延长寿命。靶向部分重编程意义重大，但用于人体 ...

In the murine system, Oct4, Sox2, c-Myc and Klf4 are sufficient to convert fibroblasts to induced pluripotent stem (iPS) cells that have many characteristics of embryonic stem (ES) cells.

Lu’s builds his work on the four transcription factors- Oct4, Sox2, Klf4, c-Myc discovered by Shinya Yamanaka. These factors can erase the cell’s epigenetic markers and return these cells to ...

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous ...