Here we provide empirical proof that the hierarchical bioactivity-guided analysis and organization of a given compound library in a scaffold tree provide an efficient, intuitively accessible means ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

SINGAPORE] Imagine a world where life-saving treatments are discovered not in decades, but in just a few years. Nanyang ...

Our research focuses on enhancing antimicrobial drug discovery – covering aspects from early target validation to detailed characterisation studies of novel antimicrobial substances. We develop fast ...

This was completed by verifying the purity and bioactivity of the CD3E&CD3D protein utilizing the bispecific antibody (AMG420) through SPR, ELISA, and SDS-PAGE. Like BsAb, IgG sustains the same ...

This review explores the convergence of traditional wisdom and modern science in the realm of herbal medicines, focusing on their safety, efficacy, and bioactivity in contemporary health care ...

The Structural Bioinformatics and Network Biology laboratory, led by ICREA Researcher Dr. Patrick Aloy, has completed the bioactivity information for a million molecules using deep machine-learning ...

Unlike conventional insulin interventions, NNC2215 was engineered to demonstrate glucose-concentration-dependent reversible responsive bioactivity. It is capable of preventing insulin overdoses ...

There is growing interest in the value of seaweeds such as sea kelp as products with important chemical (e.g., iodine) and nutritional potential. A broad understanding exits that seaweed is ‘good for ...

Biocompatibility and bioactivity are the two terms commonly used in dentistry. Generally, biocompatible materials are those materials that are well-tolerated by the biological system, whereas ...