4 The antiestrogen tamoxifen serves as a prototype of a selective estrogen receptor modulator that competitively blocks binding of estrogens. Moreover, it induces an ERα conformation that favors ...

Proliferation of MCF-7 cells is estrogen dependent and antiestrogen sensitive. In the absence of estrogens or presence of antiestrogens MCF-7 cells arrest in the G 1 phase of the cell cycle ...

Forty-three post menopausal/ovariectomized women with breast cancer who had received tamoxifen, either for metastatic disease or as adjuvant to surgery for ≥ 1 year, and had relapsed were treated in a ...

Women with breast cancer who take antiestrogen supplements may be decreasing their risk for melanoma, according to a new study. Women with breast cancer who take antiestrogen supplements may be ...

Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non–Small-Cell Lung Cancer Although antiestrogen therapies targeting estrogen receptor ...

PHILADELPHIA — Women with breast cancer who take antiestrogen supplements may be decreasing their risk for melanoma, according to a study published in Cancer Prevention Research, a journal of ...

The estrogen receptor-positive (ER+) subtype accounts for 70% of all mammary carcinoma (MC) cases. ER+ MC patients display a prolonged clinical dormancy state, with a 70% recurrence 5-20 years after ...

Selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs) are types of antiestrogen therapy for breast cancer. These medicines block estrogen ...

Women with hormone-sensitive breast cancer face years of adjuvant therapy with antiestrogen drugs, with the latest data suggesting that these drugs should now be taken for 10 years instead of the ...

Historically, breast cancer treatment is primarily composed of surgery, radiation, and some form of systemic therapy, and whether that can be chemotherapy, antiestrogen therapy, or targeted therapy.

I would not prescribe an antiestrogen, but would refer a man with poor response to Viagra-type drugs and testosterone to an expert on male sexual function. Dear Dr. Roach: At 82 years old ...

The morphologic features of the breast undergo substantial change between early adolescence and menopause. 5 The spectrum of normal histologic features ranges from a predominance of ducts, lobules ...