Targeted Oncology provides news, videos, and reviews on the rapidly evolving world of targeted therapies and immunotherapy ...

Androgens exert their effects largely by binding to nuclear androgen receptors to regulate gene expression, but they can also bind to receptors in plasma membranes to rapidly induce cellular ...

We systematically searched PubMed, Scopus, Embase, and Cochrane databases for randomized clinical trials that compared definitive radiotherapy with or without ADT in localized prostate cancer. The ...

在 CRPC 的发生发展过程中，雄激素受体（androgen receptor，AR）的持续激活起着关键作用。虽然恩杂鲁胺（enzalutamide，ENZA）是治疗 CRPC 的一线药物，但患者常常会出现耐药，导致肿瘤复发和转移。此外，非编码 RNA，尤其是长链非编码 RNA（long non-coding RNAs，lncRNAs），在癌症调控中具有重要作用，但在 PCa ...

This rare sexual development disorder is known as androgen insensitivity syndrome (AIS). This condition was previously referred to as testicular feminization syndrome. Children with androgen ...

Ltd. has described androgen receptor full length (AR-FL) and/or androgen receptor variant 7 (AR-v7) degradation inducers reported to be useful for the treatment of acne vulgaris, androgenic alopecia, ...

sll.se Background The role of endogenous androgens for body composition and physical performance in women athletes is still not elucidated. Aim To examine the serum androgen profile in relation to ...

Androgen receptor non-canonical domain binding degrader for treatment of relapsed, refractory castration-resistant prostate cancer: K. Sadasivan Pillai Wednesday, March 5, 2025, 0 ...

Haisco Pharmaceutical Group Co. Ltd. has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an androgen receptor (AR) ...

On Dec 12, 2024, the US Food and Drug Administration (FDA) approved crinecerfont for adults and paediatric patients with ...