NO and NO-donors are well-known sGC activators and the examples of drugs that work as NO-donors include nitroglycerine, minoxidil, sodium nitroprusside, and S-nitrosylated derivatives of other drugs.

This prompted us to investigate the influence of different PPAR- activators on cholesterol metabolism and foam-cell formation of human primary and THP-1 macrophages. Here we show that PPAR-α and ...

Lysoway Therapeutics Inc. has synthesized mucolipin-1 (MCOLN1; TRPML1) activators reported to be useful for the treatment of age-related macular degeneration, aging, Alzheimer’s disease, cancer, ...

Researchers reveal largest catalog of gene activators Date: February 11, 2022 Source: University of Toronto Summary: Researchers have created a functional catalog of proteins that activate gene ...

17 issue of the journal Nature. "We show that these E2fs are gene activators in stem cells but then switch to gene repressors when stem cells begin differentiating," says Gustavo Leone ...

And there is an opportunity there for proteasome activators because they are capable of targeting multiple proteins in diverse pathways. In fact, the failure of single target treatments for ...