Initially, the chromosome was synthesized in segments called megachunks, which were then cloned into vectors and integrated into yeast strains through homologous recombination. Each megachunk ...

To tackle the conundrum, Yingjin Yuan, a professor of biochemical engineering at Tianjin University, turned to deoxyribonucleic acid (DNA) and has designed yeast artificial chromosomes as a ...

Scientists have engineered a chromosome entirely from scratch that will contribute to the production of the world’s first synthetic yeast. Researchers in the Manchester Institute of Biotechnology (MIB ...

DSBs made by Spo11 activate ATM/Tel1, which inhibits further DSB formation by other Spo11 proteins. B. Interactions between chromosomes, dependent on ZMM proteins in yeast, feed back to inhibit Spo11.

Sometimes, the most significant scientific discoveries happen by accident. Scientists have long known that whole-genome ...

Researchers have generated a full-length clone of the novel coronavirus genome using artificial chromosomes in brewers’ yeast, according to a paper published in Nature on Monday (May 4). While other ...