The story begins with the Aztec God of death and lightning, the Xolotl. As legends have it, he was a monstrous dog that guarded the sun god and ushered souls to the underworld every night.

With the world under threat of eternal darkness, Lara Croft must carve a path through an army of the undead to defeat Xolotl, the Aztec god of death and misfortune.