本研究通过创新性BRET技术和单分子追踪，揭示了WNT配体诱导Frizzled(FZD)与LRP6受体结合的新机制：尽管WNT-16B能有效促进FZD-LRP6 ...

19 WNT proteins couple to more than 15 receptors and co-receptors in seven protein families: Frizzled, low-density lipoprotein receptor-related protein 5 (LRP5) and LRP6, receptor Tyr kinase-like ...

The canonical Wnt signaling pathway participates in synapse function and stability, and previous research confirmed its impairment in Alzheimer's disease (AD). Altered Wnt signaling and synapse loss ...

"The opportunity arose to test a novel WNT signaling pathway that would turn on signaling in the blood-brain barrier by binding very selectively to a receptor called frizzled." Scientists have ...

Beneath the five blocks is a much more detailed site navigation table that directs visitors to pages focused on specific components of the Wnt signaling pathway (such as the frizzled and ...

we demonstrate that the cytoplasm-to-membrane translocation of the low-density lipoprotein receptor-related protein-6 (LRP6), a membrane-bound coreceptor for the canonical Wnt pathway, triggers ...

Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...

LRP6 is a co-receptor for Wnt, which plays a crucial role in embryogenesis and development and perhaps also adult neurogenesis (see ARF related news story). The finding suggests that Wnt signaling ...

“An important issue will be to what extent Wnt signaling mediates the functional consequences of progranulin deficiency. Is it a secondary effect or integral part of the detrimental effects of ...

New research shows that the Wnt receptor Frizzled-9 (Fzd9) promotes bone formation, providing a potential new target for the treatment of osteoporosis. New research shows that the Wnt receptor ...