Wnt信号通路（Wnt signaling pathway）作为神经系统发育的关键调控者，其基因变异与老年人轻度认知障碍（MCI）的关联机制尚不明确。来自山东青岛的研究团队对17个村庄459名老年人展开横断面研究，检测9个Wnt通路基因的46个单核苷酸多态性（SNP），采用蒙特利尔 ...

These signalling systems operate beyond cell and tissue boundaries, but function as morphogens that are secreted from one cell or tissue type to activate surface receptors, signal transduction ...

Of particular significance was the finding that T3 rapidly repressed the expression of a host of key regulators of the tumor-promoting Wnt signaling pathway and the transcriptional activity of the ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling. The ...

The Wnt signaling pathway is a conserved network that regulates cell proliferation, differentiation, and migration. It consists of the canonical Wnt/β-catenin pathway and non-canonical pathways ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

At present, tankyrases are attracting significant attention as emerging therapeutic targets for cancer, principally due to their role in regulating the Wnt signaling pathway. Aberrant Wnt/β ...