Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we ...

综述：靶向癌症干细胞的先进药物递送平台 《Asian Journal of Pharmaceutical Sciences》：Advanced drug delivery platforms target cancer stem cells ...

Wnt信号通路在人类胚胎发育以及维持细胞干性等方面起着至关重要的作用。Wnt信号异常会导致发育相关疾病或者癌症。目前为止，已经在人类中鉴定 ...

在体内实验中，将靶向细胞外基质软化与抑制机械转导的策略相结合，能够显著减弱肿瘤的干性和化疗耐药性。因此，这些研究结果凸显了细胞外基质通过生物力学依赖方式调控癌症干细胞的作用，表明 ecm/itgb1/fermt1/wnt 轴有望成为癌症干细胞治疗的潜在靶点。

总之，本研究已将 hnRNPA2B1/NEAT1/Wnt 通路确定为癌症干性的新型上游调节因子，为癌症中癌细胞干性的失调提供了见解（图 9）。 hnRNPA2B1介导的NEAT1 ...

该成果首次鉴定了Wnt和TGFβ在调节大小依赖行为中的角色，证实了发育模式化能够协调控制组织生长与大小依赖的各种功能，加深了人们对生物体 ...

Conclusions: Our study highlights the crosstalk between Notch and wnt-beta-catenin in GC CD44+ cells. GSI could be an alternative drug to treat human GC as it effectively targets the CD44+ GC cells ...

因此，cd44基因敲除可改善血管内皮细胞中与年龄相关的表型。 内皮特异性CD44ICD敲入小鼠寿命较短，血管内皮细胞表现出明显的过早衰老特征，与 ...

Researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings shed light on the ...

As few as 100 cells injected in NOD-SCID mice were able to generate tumors in 50% of mice (six of 12), while tumors did not form in mice until at least 10,000 CD44−CD24−ESA− cells were injected, where ...

Wnt proteins contain palmitoleic acid, an unusual lipid modification. Production of an active Wnt signal requires the acyltransferase Porcupine (Porcn) and depends on the attachment of palmitoleic ...