How does DNA recombination work? It occurs frequently in many different cell types, and it has important implications for genomic integrity, evolution, and human disease. In the alternate pathway ...

Recombination events in many organisms are concentrated in highly localized areas termed 'hot spots'. Hot spots can be detected by statistical analysis of genetic variation, analysis of pedigrees ...

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic ...

Complete recombination map of the human genome, a major step in geneticsScientists at deCODE genetics/Amgen have constructed a complete map of how ...

Scientists reveal new insights into the hidden processes driving human genetic variation with the first complete human DNA ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Recombinant DNA is one of the first stories in modern biotechnology history. The National Museum of American History contains collections which trace this foundational technique of genetic engineering ...

Bjarni V. Halldorsson and Kari Stefansson, scientists at deCODE genetics, discuss the paper: Complete recombination map of ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...