On post hoc analysis (data not shown), even after adjustment for differences in the baseline Confidence Index scores, the valproic acid group had significantly worse scores at the week 16 and week ...

Exposure to valproic acid monotherapy was recorded for a total of 180 registrations, with 122 registrations in the case group, 45 in control group 1, and 13 in control group 2.

To investigate the potential interactive effects of a high-fat diet (HFD) and valproic acid (VPA) on hepatic steatosis and hepatotoxicity in rats. Male SD rats were orally administered VPA (100 or ...

June 9, 2010 — A new study confirms that first-trimester exposure to valproic acid is associated with an increased risk for spina bifida compared with no use of antiepileptic drugs or with use ...

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations . Jentink J, Loane MA, Dolk H, et.al., for the EUROCAT Antiepileptic Study Working Group ...

Valproic acid dissociates to form valproate ions in the body, which has numerous effects on the neuronal tissue in the brain. This accounts for its broad clinical activity and use in several ...

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. Authors: Caroline Happold, Thierry Gorlia, ...

Valproic acid first hit the market in the 1960s as an anticonvulsant medication, but by the 1980s, the drug's link to birth defects became apparent, according to BBC News.

Valproic acid is known to cause major congenital malformations when some women take the medication throughout pregnancy. Neural tube defects such as spina bifida are the main concern, ...

The Bumpus laboratory studies how drugs are processed in cells by enzymes of the cytochrome P450 family. Humans have 57 of these enzymes, and several of them work on the drug valproic acid.