Exposure to valproic acid monotherapy was recorded for a total of 180 registrations, with 122 registrations in the case group, 45 in control group 1, and 13 in control group 2.

June 9, 2010 — A new study confirms that first-trimester exposure to valproic acid is associated with an increased risk for spina bifida compared with no use of antiepileptic drugs or with use ...

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations . Jentink J, Loane MA, Dolk H, et.al., for the EUROCAT Antiepileptic Study Working Group ...

On post hoc analysis (data not shown), even after adjustment for differences in the baseline Confidence Index scores, the valproic acid group had significantly worse scores at the week 16 and week ...

Women prescribed valproic acid (10.4% of the group of pregnant women prescribed anti-epileptic medication) had a 19 times greater risk of having a baby with spina bifida compared with women who ...

Valproic acid (VPA) is an approved treatment for epilepsy, bipolar disorder, migraine headache and pain management. ... While minimal visual field change occurred in the placebo group, ...

Valproic acid first hit the market in the 1960s as an anticonvulsant medication, but by the 1980s, the drug's link to birth defects became apparent, according to BBC News.

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. Authors: Caroline Happold, Thierry Gorlia, ...

The Bumpus laboratory studies how drugs are processed in cells by enzymes of the cytochrome P450 family. Humans have 57 of these enzymes, and several of them work on the drug valproic acid.