Disease progression eventually occurs in many patients that were included in these trials, raising the issue that undiscovered pathways mediate angiogenic escape after VEGF inhibition. Different ...

These findings suggest that, although VEGF signaling may be a rate-limiting step in a wide variety of circumstances, local regulatory pathways modulate endothelial-cell growth and function in a ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Conventional anti-VEGF therapies primarily target immature blood vessels in tumors. The combinational targeting of both ANGPT2 and VEGF pathways is now expected to improve clinical efficacy by ...

Angiogenesis plays a major role in cancer and VEGF-targeted agents have been shown ... to function as effective inhibitors of signaling pathways. Combining minimal doses of chemotherapy ...

A groundbreaking review highlights significant advancements in the understanding and treatment of cerebral vascular ...

AbbVie (NYSE: ABBV) and REGENXBIO Inc. (Nasdaq: RGNX) today announced updates to the ABBV-RGX-314 clinical program.

The drug is designed to block the PD1 and VEGF pathways while minimising VEGF-related adverse effects, "specifically due to its intentionally designed interaction with VEGFR2," according to Ottimo.

This innovative therapeutic approach is designed to inhibit both PD-1/PD-L1 and VEGF/VEGFR receptor signaling pathways releasing a key immune checkpoint while also inhibiting the production of new ...