Thus, in the absence of NGLY1, Nrf1 is detected as a stable ubiquitinated protein in the cytosol, and this ubiquitination prevents Nrf1 from nuclear transport. The proteasome is a major player in ...

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts ...

Yulan Huang, Yuan Gao, Zhenghong Lin, Hongming Miao, Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression, Genes & Diseases, Volume 12 ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

By influencing these pathways, ubiquitination emerges as a potentially powerful therapeutic target to disrupt the aggressive nature of CSCs. The involvement of the Ub-proteasome system (UPS ...

By influencing these pathways, ubiquitination emerges as a potentially powerful therapeutic target to disrupt the aggressive ...

The proteasome, being the final destination for proteins tagged for proteolytic degradation, is intimately associated with the ubiquitination pathway, one which flags proteins with strings of the ...

A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, "Restoring our ubiquitination ... Center discuss the ubiquitin-proteasome system (UPS), which is usually ...