Figure 3: Reporter accumulation in livers of proteasome ... of the ubiquitin/proteasome system becomes evident, which is consistent with our previous results from a cellular model for proteasomal ...

In addition, components of the ubiquitin–proteasome system, most notably the proteasome itself, have a direct role in the regulation of gene expression. The authors propose a model in which ...

A Complex Role in Cellular Process & Growing Tool Set to Elucidate It It is increasingly clear that the ubiquitin-proteasome-system (UPS) is misnamed. Ubiquitylation is not just about targeting ...

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism ...

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

In this new editorial, researchers Xiaoling Li and Ping Mu from the University of Southwestern Medical Center discuss the ubiquitin-proteasome system (UPS), which is usually responsible for ...

has raised $63 million in series A funding to pioneer a novel class of small-molecule drugs, designed to selectively stabilize proteins that would otherwise undergo degradation in the ...

That's why three papers in the November 21 issue of the Proceedings of the National Academy of Sciences (PNAS) are so significant. Building upon discoveries over the past decade about certain ...

The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis.