Figure 1: Discovery of the ligation of ubiquitin to lysozyme ... and degraded by the proteasome. Removal of the MHC molecules enables the virus to evade the immune system. A completely different ...
They report in Cell this week that the system involves a ubiquitin-protein ligase that specifically targets four distinct mutant nuclear proteins for destruction by the proteasome ... Artificial ...
The N-end rule pathway, ubiquitin-dependent in eukaryotes, is also present in prokaryotes, which lack the ubiquitin system ... by specific subunits of the 26S proteasome, which unfolds and ...
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