Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...

Discovery of a NEDD8 modification system regulating the cell cycle: During in vitro translation analysis of full-length cDNA clones, a ubiquitin-like protein, NEDD8, was found to covalently modify ...

The authors of this article show that EGCG inhibited NEDD8, thus stabilizing HUWE1, a crucial E3 ubiquitin ligase involved in protein degradation. HUWE1 binds and degrades TFR1, a protein ...