Ubiquitin is a small protein that is ... the corresponding genes probably arose from a polyubiquitin-encoding gene that had acquired a sequence encoding the BIL domain. The β-grasp fold shared ...

They possess a distinct primary sequence but share characteristic ... and mammalian cells point out another role of ubiquitin and Ubls in DNA repair, apoptosis and cell-cycle control.

We also determined the structural basis for ubiquitin E1-E2 thioester bond formation. The structural and biochemical basis for E2-dependent protein conjugation was uncovered by analysis of a complex ...

such as gene transcription and immune function. These breakthrough discoveries earned them the Nobel Prize in Chemistry in 2004. Through these steps, the ubiquitin molecule forms an isopeptide ...

The ubiquitin gene profile helped identify the specific biological characteristics and clinical prognosis linked to these patients’ organs. A comprehensive analysis based on biocomputational and ...

A catalyst called tetrazole was added to bind bases into a single-strand sequence of DNA; advanced optics made perfect alignment possible. The upshot was that instead of producing 96 pieces of DNA ...

Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study ...

Scientists who disrupted one type of the gene ubiquitin (Ubb) in mice observed neuronal death in the hypothalamus, impaired control of energy balance and adult-onset obesity in the rodents.

Louis removed the ubiquitin gene RNF8 in neurons in the cerebellum of young mice, and found that neurons lacking the RNF8 protein formed about 50 percent more synapses, the connections that allow ...

Human genes are made of small parts, called exons, which are separated by long non-coding DNA sequences, called introns. When a gene is transcribed, the intervening introns are cut or “spliced ...