针对三阴性乳腺癌（TNBC）免疫治疗单药疗效有限的问题，研究人员探讨 UCH-L1（泛素羧基末端水解酶 L1）在 TNBC 免疫治疗中的作用。发现 UCH-L1 通过稳定 E3 泛素连接酶 ARIH1 促进 PD-L1 降解，抑制 UCH-L1 联合 PD-L1 抗体可增强疗效，为 TNBC 免疫治疗提供新策略。

为解决 S100B 和 GFAP/UCH-L1 在 mTBI 创伤性颅内病变检测中的应用问题，研究人员对比两者，发现两者诊断性能相似，支持 GFAP/UCH-L1 作替代。 创伤性脑损伤诊断新探：S100B 与 GFAP/UCH-L1 的较量 在生活中，头部受伤的情况时有发生，而轻度创伤性脑损伤（mTBI）更是常见。

The scientists ran blood tests on the study participants at their initial visits, looking for two biomarkers, called GFAP and UCH-L1, which are released into the bloodstream after a head injury.

The levels of biomarkers GFAP, UCH-L1, and MAP-2 are significantly elevated within 30 and 60 minutes of traumatic brain injury (TBI), thereby facilitating early diagnosis. GFAP demonstrates the ...

The researchers linked the changes in circulating UCH-L1 and GFAP proteins in rats to brain tissue damage and neuronal degeneration seen on examination of the rat brains and present their findings ...

Objective To characterize levels of plasma GFAP, NF-L, UCH-L1, T-tau, and p-tau181 in healthy youth athletes considering the influence of previous concussion, age, sex, menstrual cycle stage, and sex ...

The rapid assay looks for two protein biomarkers — GFAP, found in glial cells, and UCH-L1, found in neurons. Tests of both biomarkers have been approved by the Food and Drug Administration for ...

Results published in The Lancet Neurology reveal that higher values of two protein biomarkers, GFAP and UCH-L1, are associated with death and severe injury. This is the first study to examine the ...

The Brain Trauma Indicator test measures two biomarkers: proteins known as UCH-L1 and GFAP that are released upon injury to the brain and pass through the blood-brain barrier. Elevated levels of ...

Last year, the U.S. Food and Drug Administration approved the first core laboratory test that can screen for two biomarkers associated with brain injury, known as GFAP and UCH-L1. The new test ...