C.M. Laumont et al., “Noncoding regions are the main source of targetable tumor-specific antigens,” Sci Transl Med, 10:eaau5516, 2019. In pursuit of safe and effective cancer therapies, researchers ...

In 2021, research led by Ryan Flynn, MD, Ph.D., and his mentor, Nobel laureate Carolyn Bertozzi, Ph.D., opened a new chapter ...

When expressed together on the surface of NG-348-infected tumor ... does not require selection for any given tumor-specific antigens and is directed toward solid tumors. In 2016, Bristol-Myers ...

rely on the immune system recognizing cancer-specific ‘non-self’ antigens. These antigens are bound to human leukocyte antigen (HLA) molecules, which help differentiate between self- and non ...

Our body's own defense system not only clears away bacteria and viruses, it can also fight cancer. However, not all tumor ...

Researchers show that glycoRNAs, uncovered by the lab of Nobel Laureate, Carolyn Bertozzi, can be used to fight cancer.

TCERs are engineered, antibody-like molecules that leverage the body’s immune system by redirecting and activating T cells towards cancer cells expressing specific tumor targets. The design of ...

A newly developed radiolabeled antibody that targets the cancer antigen IL13Rα2 has been found to be highly specific, binding ...

Advancements in mRNA vaccine technology are reshaping medicine, addressing challenges and expanding applications from ...

These approaches include monoclonal antibodies against tumor antigens, checkpoint inhibitors that block tumors from accessing suppressive proteins on immune cells, and chimeric antigen receptor (CAR) ...

In this case, the tumor on the right was irradiated; the left one was not ... Ruggiero A, Holland JP, Hudolin T, Shenker L, Koulova, A, Bander N, Lewis JS, Grimm J (2011) Targeting the internal ...

Such T cells have been genetically modified by incorporation of a replication-incompetent vector (NIT) for an inactive mutant nerve growth factor receptor (LNGFR) as an immunoselectable surface marker ...