rely on the immune system recognizing cancer-specific ‘non-self’ antigens. These antigens are bound to human leukocyte ...

Amid an evolving landscape of anticancer agents, numerous approaches to elicit tumor-specific ... with antigen-positive tumors; the number of potential antigenic epitopes; and surface expression ...

antigen expression in cancer stem cells; the frequency of patients with antigen-positive tumors; the number of potential antigenic epitopes; and surface expression of the antigen. From published ...

These approaches include monoclonal antibodies against tumor antigens, checkpoint inhibitors that block tumors from accessing suppressive proteins on immune cells, and chimeric antigen receptor (CAR) ...

Advancements in Antigen Selection for CRC CAR-T Cell Therapies Introducing specific targets for CAR-T cell therapy in CRC is essential ... 37 Natural killer group 2 member D ligands are stress-induced ...

Medically reviewed by Doru Paul, MD Immunotherapy can boost your body’s immune response to cancer cells and hopefully kill them. For those with triple-negative breast cancer, immunotherapy can make a ...

More than two decades ago, UChicago researchers began testing “cancer vaccines” that aimed to elevate a person's level of antigen-specific T cells. These are specific white blood cells that can ...

Chimeric antigen receptor-T (CAR-T) cell therapy ... potential of CAR-T cell therapy in CRC by analyzing clinical trials and highlighting prominent CRC-specific targets. We discuss the challenges such ...

Researchers have discovered that some CAR-T cells engineered to fight cancer ... no antigen experience. A direct comparison of the two cell types allowed the researchers to identify specific ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...