The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses.

[1] In their report, the authors develop weighted criteria to prioritize tumor vaccine antigens with the goal of identifying rational criteria to move individual antigens forward in development ...

avoid rejection by the host immune system and provide durable responses. “Our engineered cells express T cell receptors and/or CARs that have been optimized to target multiple cancer antigens ...

B cells contribute to the rejection of skin allografts by presenting donor antigens to T cells, via opsonizing donor cells (through binding of alloantibodies) and via direct complement-dependent ...

The U.S. Court of Appeals for the Federal Circuit (CAFC) today affirmed a Patent Trial and Appeal Board (PTAB) decision that ...