Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of ...

However, as tumors evolve, they exploit the TIME to ... thereby influencing processes like immune escape, angiogenesis, and ...

Many of the cells in the innate immune system produce cytokines or interact with other cells directly to activate the adaptive immune system. In cancer cells, mutations can lead to expression of tumor ...

Melanoma cells, the most aggressive form of skin cancer, produce a protein that blocks the recognition and removal of the ...

A new study from Memorial Sloan Kettering Cancer Center has shown that an RNA-based neoantigen vaccine can generate long-lasting immune cells that may help slow the recurrence of pancreatic ductal ...

Immunotherapy is a treatment that strengthens the ability of the patient’s own immune system to detect and destroy cancer. Cancer cells often have mutations that allow them to escape the immune system ...

Tryptophan 2,3-dioxygenase (TDO), as a key rate-limiting enzyme, is widely involved in tryptophan metabolism and the regulation of various physiological and pathological processes. TDO activity can be ...

Get Instant Summarized Text (Gist) Cancer disrupts T cell energy management, particularly in chronic lymphocytic leukemia (CLL), leading to impaired immune responses. T cells fail to increase ...