Tumor antigens come in one of two categories: tumor associated antigens (TAA) and tumor specific antigens (TSA). 2 TAA are found on normal cells but at much lower densities than on cancerous cells.

or tumor-associated antigens (TAAs). TSA, exclusive to tumor cells, minimizes on-target off-tumor toxicity (OTOT) risks, whereas TAA, also found on normal cells, may cause OTOTs. Fig 1. Similarity and ...

For example, one program is developing a BsAb with binding sites for tumor-associated antigen (TAA) and 4-1BB (also known as CD137), an inducible costimulatory molecule found on a number of cell ...