The selective advantage for the establishment and, more interestingly, the maintenance of heterogeneity in tumors is unclear. Our results indicate that tumors benefit collectively from protecting ...

This is particularly evident in the context of both infectious disease and cancer, where a great deal of heterogeneity is observed both within individual patient tumors and between patients. A major ...

(Top middle) Tumor heterogeneity: CRC tumors exhibit significant intratumoral heterogeneity, making it difficult for CAR-T cells to target all malignant clones effectively, as different subclones may ...

Even with cancer-associated antigens studding ... strategy for treating patients with tumors with high heterogeneity. Patterns of antigen architectures in patient tumors correlated with T cell ...

Chimeric antigen receptor (CAR ... we don't have enough of a therapeutic effect before we get toxicity." Tumor-cell ...