Although the potential interaction between transplantation and tumor immunology ... be on the same cell. Co-expression of helper and cytotoxic determinants by the same antigen presenting cells ...

the specificity of the antigen expression to tumor cells; the frequency of antigen expression in tumor cells; antigen expression in cancer stem cells; the frequency of patients with antigen ...

Utilizing an analytic hierarchy process (AHP) based on preidentified criteria and weighted by a panel of experts, Cheever and colleagues constructed priority rankings of 75 cancer antigens.

Researchers at Cellectis leveraged gene editing to create a CAR T cell that acts in an IF/THEN system. Traditional methods to develop CAR T cells that use the patient’s cells introduce challenges ...

Advancements in Antigen Selection for CRC CAR-T Cell Therapies Introducing specific targets for CAR-T cell therapy in CRC is essential for enhancing the efficacy and specificity of the treatment.

These neoepitopes are formed not only from the nonsynonymous mutations that occur in cancer cells but also from abnormalities ...

For example, activation of a synthetic Notch (synNotch) receptor that binds one antigen can trigger the expression of a CAR targeting another antigen ... similar to a CAR, they bind to tumor antigens.