微管是由a-tubulin/b-tubulin异源二聚体在GTP存在下形成的由13条微管原丝环绕形成的中空管状复合物（除鞭毛、纤毛中的特质化微 ...

为解决 DCX 在神经元迁移中作用机制不明等问题，麦吉尔大学研究人员开展 DCX 相关研究，发现 DCX 通过调节 α -tubulin 多聚谷氨酸化限制神经突分支。该成果有助于理解相关脑部疾病，推荐科研读者阅读。 在人类大脑发育的奇妙旅程中，神经元的迁移和正确定位 ...

Researchers have shed light on the mechanisms governing the dynamics of microtubules – the vital protein structures forming ...

In a study published in Proceedings of the National Academy of Sciences , researchers from Queen Mary University of London ...

The tubulin family of proteins are vital components of the eukaryotic cytoskeleton and are the main constituent of microtubules in living cells. The tubulin proteins α- and β polymerize into ...

So targeting the TRiC-assisted tubulin folding process could provide an attractive anti-cancer strategy. The team reported the results of their decade-long study in a paper published in Cell today.

Tubulin was found to be a major component of the MEC, with non-microtubule tubulin widely distributed on the purified PSD lattice. The presence of tubulin in and around PSDs was verified by post ...

First PROTAC against tubulin divulged Feb. 16, 2024 Researchers from Zjengzhou University reported on the discovery and preclinical characterization of a novel PROTAC agent aimed at overcoming ...

A phase I study with exploratory pharmacodynamic endpoints of XL647, a novel spectrum selective kinase inhibitor, administered orally daily to patients (pts) with advanced solid malignancies ...

Timing of docetaxel chemotherapy and impact on outcomes in metastatic castrate-resistant prostate cancer (MCRPC). This is an ASCO Meeting Abstract from the 2019 Genitourinary Cancers Symposium. This ...